Pathogenicity and Transcriptomic Profiling Revealed Activation of Apoptosis and Pyroptosis in Brain of Mice Infected with the Beta Variant of SARS-CoV-2.
These findings elucidate mechanisms of neuropathogenicity associated with the SARS-CoV-2 beta variant and highlight therapeutic targets to mitigate COVID-19-related neurological dysfunction.
Authors
- Bingru Huang (ORCID: https://orcid.org/0000-0002-9652-9413)
- Xiaoyun Shen (ORCID: https://orcid.org/0000-0003-2098-9728)
- Li Han (ORCID: https://orcid.org/0000-0003-3436-2811)
- Weibang Huo (ORCID: https://orcid.org/0009-0004-2210-8239)
- Zhiyong Zhang (ORCID: https://orcid.org/0000-0003-1622-3447)
- Fei Ye (ORCID: https://orcid.org/0000-0002-8939-2922)
- Guoqiang Zhang (ORCID: https://orcid.org/0000-0003-1728-3847)
- Wen Wang (ORCID: https://orcid.org/0000-0003-4120-0773)
- Li Zhao (ORCID: https://orcid.org/0000-0003-1576-8787)
- Wen Ling Wang
- Wen Jie Tan
- Chang Cheng Wu
Institutions
- Chinese Center For Disease Control and Prevention (CN)
- National Institute for Viral Disease Control and Prevention (CN)
- National Institute for Communicable Disease Control and Prevention (CN)
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-09-20
- DOI
- https://doi.org/10.3967/bes2025.106
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00