Human Cytomegalovirus Infection and Embryonic Malformations: The Role of the <i>Wnt</i> Signaling Pathway and Management Strategies.
Human cytomegalovirus (HCMV) poses a significant risk of neural damage during pregnancy. As the most prevalent intrauterine infectious agent in low- and middle-income countries, HCMV disrupts the development of neural stem cells, leading to fetal malformations and abnormal structural and physiological functions in the fetal brain. This review summarizes the current understanding of how HCMV infection dysregulates the <i>Wnt</i> signaling pathway to induce fetal malformations and discusses current management strategies.
Authors
- Bowen Zheng (ORCID: https://orcid.org/0009-0003-0352-8257)
- Sicheng Huang (ORCID: https://orcid.org/0000-0003-2191-5018)
- Zhi Jun Liu
- Xu Han (ORCID: https://orcid.org/0000-0003-0720-2038)
- Dong Wang (ORCID: https://orcid.org/0000-0003-2475-0642)
- Jun Chen (ORCID: https://orcid.org/0000-0003-2447-0544)
- Lin Xiao (ORCID: https://orcid.org/0000-0003-2740-7014)
- Zhi Liu
Institutions
- Ministry of Education (ET)
Publication Details
- Journal
- PubMed
- Published
- 2025-09-20
- DOI
- https://doi.org/10.3967/bes2025.103
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00