Apigenin Induces Autophagy and Apoptosis in Chemoresistant Glioblastoma Cells and Inhibits Tumorigenicity Associated with Regulation of Immunomodulatory Proteins and Glial Cells Response
These results demonstrate that apigenin inhibits the growth of tumoral cells, affecting the viability of tumor stem cells and impairing tumorigenicity, while altering the regulatory profile of immunomodulatory proteins. Therefore, this flavonoid can be considered for further studies to determine its use as an adjuvant to the treatment of human GBMs.
Authors
- Balbino Lino dos Santos (ORCID: https://orcid.org/0000-0002-6430-229X)
- Vivaldo Moura‐Neto (ORCID: https://orcid.org/0000-0002-6266-043X)
- Marie‐Pierre Junier (ORCID: https://orcid.org/0000-0002-5731-0929)
- Sílvia Lima Costa (ORCID: https://orcid.org/0000-0002-8975-3871)
- Suzana Braga‐de‐Souza (ORCID: https://orcid.org/0000-0003-4165-3318)
- Karina Costa da Silva
- Giselle Pinto de Faria Lopes (ORCID: https://orcid.org/0000-0001-9502-2314)
- Cleonice Creusa dos Santos (ORCID: https://orcid.org/0000-0001-6428-4485)
- Monique Reis de Santana (ORCID: https://orcid.org/0000-0002-0062-0176)
- Alessandra Bispo da Silva
- Maria de Fátima Dias Costa (ORCID: https://orcid.org/0000-0003-0916-2893)
- Paulo Lucas Cerqueira Coelho
- Hervé Chneiweiss (ORCID: https://orcid.org/0000-0001-7675-5061)
Institutions
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (BR)
- Universidade Federal da Bahia (BR)
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Sorbonne Université (FR)
- Instituto de Estudos do Mar Almirante Paulo Moreira (BR)
- Czech Academy of Sciences, Institute of Biophysics (CZ)
- Institut de Biologie Paris-Seine (FR)
- Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (BR)
- Instituto Estadual do Cérebro Paulo Niemeyer (BR)
- Universidade Federal do Vale do São Francisco (BR)
Publication Details
- Journal
- Cells
- Published
- 2025-10-03
- DOI
- https://doi.org/10.3390/cells14191552
- Primary Topic
- Flavonoids in Medical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Sorbonne Université