FDG-PET brain glucose hypometabolism predicts Alzheimer's disease progression pathways in cognitively normal adults: A longitudinal competing risks modeling
Based on our modeling findings, we observed that brain glucose metabolism could serve as a pathway determinant rather than simply a decline predictor, which could play a promising role in precision medicine approaches to Alzheimer's disease prevention. FDG-PET biomarkers can stratify individuals for pathway-specific interventions, transforming reactive dementia care into proactive pathway-guided management.
Authors
- James Milburn (ORCID: https://orcid.org/0000-0003-3403-2628)
- Mohammed Khalil (ORCID: https://orcid.org/0000-0002-4211-1011)
- Mustafa S. Alhasan (ORCID: https://orcid.org/0009-0002-4401-5127)
- Seham Hamoud (ORCID: https://orcid.org/0009-0004-7907-0403)
- Omar Alharthi (ORCID: https://orcid.org/0000-0002-7743-104X)
- Ayman S. Alhasan (ORCID: https://orcid.org/0000-0001-8879-4017)
- Muhammed Amir Essibayi (ORCID: https://orcid.org/0000-0001-8325-2382)
- Fabrício Stewan Feltrin (ORCID: https://orcid.org/0000-0001-6783-7655)
- Yasir Hassan Elhassan (ORCID: https://orcid.org/0000-0003-0196-5413)
- Ahmed Y. Azzam (ORCID: https://orcid.org/0000-0002-4256-0159)
- Sumit Singh (ORCID: https://orcid.org/0000-0003-3753-5861)
- Abdullah Almaghraby (ORCID: https://orcid.org/0000-0003-4956-2613)
Institutions
- University of Suffolk (GB)
- Albert Einstein College of Medicine (US)
- Montefiore Medical Center (US)
- King Abdulaziz University (SA)
- Umm al-Qura University (SA)
- Taibah University (SA)
- Ochsner Medical Center (US)
- Television Research Institute (RU)
- Neurological Surgery (US)
- Artificial Intelligence in Medicine (Canada) (CA)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Metabolism Open
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.metop.2025.100400
- Citations
- 1
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16