Immune Training of the Interleukin 6 Gene in Airway Epithelial Cells is Central to Asthma Exacerbations
An exaggerated IL-6 release is required for exacerbation of experimental asthma, potentially the result of viral PAMP-induced immune training of airway epithelial cells. Additionally, patients with asthma carrying the epigenetic signature of a trained IL-6 response exacerbate more frequently. These findings open new avenues to identify and treat exacerbation-prone patients.
Authors
- Maarten van den Berge (ORCID: https://orcid.org/0000-0002-9336-7340)
- Thomas Bahmer (ORCID: https://orcid.org/0000-0002-7677-7057)
- Zane Orinska (ORCID: https://orcid.org/0000-0003-0834-5321)
- Folke Brinkmann (ORCID: https://orcid.org/0000-0002-4307-4232)
- Carole Ober (ORCID: https://orcid.org/0000-0003-4626-9809)
- Matthias Kopp (ORCID: https://orcid.org/0000-0003-1989-5492)
- Sina Webering
- Inke Regina König (ORCID: https://orcid.org/0000-0003-0504-6465)
- Claudia A. Nold‐Petry (ORCID: https://orcid.org/0000-0002-7439-3834)
- Christoph Garbers (ORCID: https://orcid.org/0000-0003-4939-6950)
- Klaus F. Rabe (ORCID: https://orcid.org/0000-0002-7020-1401)
- Rebecca Bodenstein‐Sgró
- Marcel F. Nold (ORCID: https://orcid.org/0000-0001-9682-4618)
- Erika von Mutius (ORCID: https://orcid.org/0000-0002-8893-4515)
- Axel Künstner
- Jan Heyckendorf (ORCID: https://orcid.org/0000-0003-4203-8421)
- Ulrich M. Zissler (ORCID: https://orcid.org/0000-0003-4826-3419)
- Johanna C. Ehlers
- Bianca Schaub (ORCID: https://orcid.org/0000-0003-1652-8873)
- Constanze A. Jakwerth (ORCID: https://orcid.org/0000-0002-2902-0393)
- Karri V. V. S. Narayana Reddy (ORCID: https://orcid.org/0000-0001-9002-6930)
- Markus Weckmann (ORCID: https://orcid.org/0000-0001-5342-979X)
- Sai Sneha Priya Nemani
- Michael Wegmann (ORCID: https://orcid.org/0000-0002-1658-1554)
- Brian Gregory George Oliver (ORCID: https://orcid.org/0000-0002-7122-9262)
- Lars Lunding (ORCID: https://orcid.org/0000-0002-5278-3129)
- Cornelis J. Vermeulen (ORCID: https://orcid.org/0000-0002-3280-1414)
- Christina Vock (ORCID: https://orcid.org/0000-0003-3936-3426)
- Carsten B. Schmidt‐Weber (ORCID: https://orcid.org/0000-0002-3203-8084)
- Hauke Busch (ORCID: https://orcid.org/0000-0003-4763-4521)
- Ali Önder Yildirim (ORCID: https://orcid.org/0000-0003-1969-480X)
- Anna‐Maria Dittrich
- R Ceballos
- Gesine Hansen
Institutions
- University of Technology Sydney (AU)
- The University of Sydney (AU)
- University Medical Center Groningen (NL)
- Woolcock Institute of Medical Research (AU)
- Hudson Institute of Medical Research (AU)
- Helmholtz Zentrum München (DE)
- Medizinische Hochschule Hannover (DE)
- University of Chicago (US)
- Institute for Integrative and Experimental Genomics (DE)
- Universitäres Kinderwunschzentrum Lübeck (DE)
- Monash Children’s Hospital (AU)
- University Hospital Schleswig-Holstein (DE)
- University Children’s Hospital Bern (CH)
- Research Center Borstel - Leibniz Lung Center (DE)
- German Center for Lung Research (DE)
- Universities of Giessen and Marburg Lung Center (DE)
- LungenClinic Grosshansdorf (DE)
- Rosenheim Technical University of Applied Sciences (DE)
- AgriBio (AU)
- Monash University (AU)
- Ludwig-Maximilians-Universität München (DE)
- University of Lübeck (DE)
Publication Details
- Journal
- Allergy
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1111/all.70070
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health