Primary stabbing headache in a tertiary headache centre

Based on both our clinical observations and the published data, PSH and migraine appear closely intertwined. Although the precise mechanisms remain speculative, the high degree of comorbidity underscores the possibility that PSH and migraine share overlapping pathophysiological pathways. Our findings lend support to the hypothesis that PSH may be facilitated by an underlying migraine biology. Clinically, our data may be an under-estimate as stabbing headache is generally not the presenting issue and may not have been well recorded. Future research aimed at elucidating molecular mechanisms could further clarify the nature of this relationship and pave the way for targeted therapies.