Hypolipidemic and Hepatoprotective Effects of 5-(4-(3-thioxo-3H-1,2-dithiol-5-yl)phenoxy)Pentanoic Acid (TDPPA) on Hyperlipidemic Mice
TDPPA demonstrates potent lipid-lowering, antioxidant, and antiinflammatory activities, likely through a dual mechanism involving PPAR-α activation and HⁿSmediated hepatoprotection. These findings position TDPPA as a promising therapeutic candidate for hyperlipidemia with the benefit of liver protection.
Authors
- Yundong Xie (ORCID: https://orcid.org/0009-0008-9358-4864)
- Manjun Liu
- Xiaohong Chen (ORCID: https://orcid.org/0000-0002-9797-8384)
- Lei Zhang (ORCID: https://orcid.org/0000-0001-5454-8758)
- Qiuzhen Yuan
- Wenjing Shen
- Ting Li (ORCID: https://orcid.org/0009-0007-8797-2353)
Institutions
- Taizhou Fourth People's Hospital (CN)
- Shaanxi Provincial Hospital of Traditional Chinese Medicine (CN)
- Zigong First People's Hospital (CN)
- Shaanxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Medicinal Chemistry
- Published
- 2025-10-08
- DOI
- https://doi.org/10.2174/0115734064425298250923050512
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00