Aucubin Inhibits Liver Cancer via HMGB1-mediated Inactivation of the PI3K/AKT/mTOR Signaling Pathway
This study indicated that aucubin inhibits the proliferation, invasion, and metastasis of liver cancer by upregulating the HMGB1/RAGE axis and targeting the PI3K/AKT/mTOR signaling pathway. The results of this study highlighted the potential of aucubin as a therapeutic agent for suppressing liver cancer.
Authors
- Xuan Ma (ORCID: https://orcid.org/0000-0001-9387-8776)
- Zanjie Feng
- Weinan Li (ORCID: https://orcid.org/0009-0008-0358-9742)
- Mei Yong
- Cijun Peng
Institutions
- Guiyang Medical University (CN)
- Zunyi Medical University (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Recent Patents on Anti-Cancer Drug Discovery
- Published
- 2025-10-08
- DOI
- https://doi.org/10.2174/0115748928420661250922102242
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00