Personalizing voriconazole dosing in Chinese hematological patients: CYP2C19 phenotype and albumin-bilirubin grade as key predictors of trough concentrations
CYP2C19 phenotype, ALBI grade, sex, Ccr and concomitant use of glucocorticoids contribute to the variability of VRC <i>C</i> <sub>trough</sub> and should be comprehensively considered when determining VRC dosage in Chinese hematological patients.
Authors
- Juanjuan Huang (ORCID: https://orcid.org/0000-0002-5801-9754)
- Yanfei Li (ORCID: https://orcid.org/0000-0002-4039-4222)
- Lin Hu (ORCID: https://orcid.org/0000-0001-6098-5196)
- Xi Tang
Institutions
- Central South University (CN)
- The First Hospital of Changsha (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fphar.2025.1667461
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00