Construction of bioactive nanocomposites from beta-sitosterol, fucoidan, chitosan, and silver nanoparticles for anticancer applications
AgNPs had a mean diameter of 8.83 nm, whereas Fu/BSt/AgNPs/CS had 146.6 nm size. MTT assay revealed that IC<sub>50</sub> of Fu/BSt/AgNPs and Fu/BSt/AgNPs/CS nanocomposites were 16.23, 12.75 mg/L against HCT-116 cells, and 34.81, 22.44 mg/L against A375 cells, respectively, which significantly exceeded the cisplatin IC<sub>50</sub> (25.56 and 79.77, respectively). The cancer cells' treatment with nanocomposites revealed significant apoptosis induction and cell growth inhibition. Ultra-structural imaging confirmed the nanocomposites' ability to trigger cancer cells to undergo morphological alterations, destructions and collapse. Invented Fu/BSt/AgNPs/CS nanocomposites have great promises as safe and effective treatments for colon and skin cancers, generated from natural compounds.
Authors
- Fatma Khaled Elagezy
- Mohamed E. El‐Hefnawy (ORCID: https://orcid.org/0000-0002-0202-8045)
- Ahmed A. Tayel (ORCID: https://orcid.org/0000-0001-9411-134X)
- Asmaa Abdella (ORCID: https://orcid.org/0000-0002-3499-3448)
- Shaymaa W. El‐Far (ORCID: https://orcid.org/0000-0002-9422-6371)
- Hend A. Gad
- Sultan Alhayyani (ORCID: https://orcid.org/0000-0002-6529-9299)
Institutions
- Kafrelsheikh University (EG)
- Taif University (SA)
- King Abdulaziz University (SA)
- University of Sadat City (EG)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fbioe.2025.1668888
- Primary Topic
- Seaweed-derived Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- King Abdulaziz University
- Taif University