Is it possible to prevent excessive synaptic pruning in schizophrenia? Possibilities and limitations
Targeted modulation of synaptic pruning represents a promising but complex therapeutic strategy. The timing, specificity, and reversibility of interventions are crucial to avoid disrupting essential neurodevelopment. Future efforts should focus on identifying biomarkers for patient stratification and validating preventive strategies in high-risk populations.
Authors
- Agata Gabryelska (ORCID: https://orcid.org/0000-0002-4430-6488)
- Zofia Kotkowska
- Magdalena Kotlicka‐Antczak (ORCID: https://orcid.org/0000-0001-5755-6198)
- Agnieszka Pawlak (ORCID: https://orcid.org/0000-0001-9032-9130)
- Marcin Sochal (ORCID: https://orcid.org/0000-0003-2122-0304)
- Dominik Strzelecki (ORCID: https://orcid.org/0000-0002-8559-1078)
- Jakub Stefanowicz
- Filip Napieraj
Institutions
- Medical University of Warsaw (PL)
- Medical University of Lodz (PL)
Publication Details
- Journal
- Frontiers in Synaptic Neuroscience
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fnsyn.2025.1656232
- Citations
- 1
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.91