Isorhamnetin as a promising agent for reducing diabetes-induced cardiac damage: insights into antioxidant and enzyme regulatory mechanisms
Isorhamnetin plays a cardioprotective effect in diabetic rats by reducing oxidative stress, increased antioxidant defense, restored and enzyme activity of ATPase and reduced inflammation and apoptosis. Hence, Isorhamnetin can be used as a promising multi-target drug for diabetes-induced cardiac and injury.
Authors
- Yousra Bseiso (ORCID: https://orcid.org/0000-0002-4346-5049)
- Abdelrahim M. Alqudah (ORCID: https://orcid.org/0000-0003-3721-8225)
- Alaa A. A. Aljabali (ORCID: https://orcid.org/0000-0002-9519-6338)
- Mohammed Wedyan (ORCID: https://orcid.org/0000-0002-8693-5506)
- Badriyah Shadid Alotaibi (ORCID: https://orcid.org/0000-0002-4066-5694)
- Taher Hatahet (ORCID: https://orcid.org/0000-0003-0171-3304)
- Esam Y. Qnais (ORCID: https://orcid.org/0000-0002-6203-4527)
- Omar Gammoh (ORCID: https://orcid.org/0000-0001-8801-2652)
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Hashemite University (JO)
- Bangor University (GB)
- Yarmouk University (JO)
Publication Details
- Journal
- Molecular Biology Reports
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1007/s11033-025-10941-1
- Primary Topic
- Phytochemical and Pharmacological Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Princess Nourah Bint Abdulrahman University