Hemorrhagic Transformation in Pneumococcal Meningitis: A Rare but Devastating Complication

Bacterial meningitis is a neurological emergency with significant morbidity and mortality. Streptococcus pneumoniae is the leading cause in adults, with complications such as cerebral infarction, hydrocephalus, and seizures. Haemorrhagic transformation is extremely rare, reported in 2–9% of cases, but is associated with poor prognosis. We report a case of pneumococcal meningitis complicated by extensive frontal lobe and cerebellar haemorrhages. The patient presented with classic meningitis symptoms and rapidly developed a generalized tonic–clonic seizure. Neuroimaging revealed multiple haemorrhages without vascular malformations, hypertension, anticoagulant exposure, or coagulopathy. Venous sinus thrombosis was excluded. Systemic sepsis and vasculitis were considered the likely contributors to haemorrhagic transformation. Despite the severity, the patient showed significant neurological recovery following targeted antibiotics, intensive care, and multidisciplinary rehabilitation. This case emphasizes the need for early neuroimaging in meningitis patients with neurological decline, even in the absence of vascular risk factors, to enable timely recognition and intervention. Bangladesh Crit Care J September 2025; 13 (2): 120-123

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Journal
Bangladesh Critical Care Journal
Published
2025-10-16
DOI
https://doi.org/10.3329/bccj.v13i2.84409
Primary Topic
Pneumonia and Respiratory Infections
Type
article
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article

Hemorrhagic Transformation in Pneumococcal Meningitis: A Rare but Devastating Complication

Vikas Dutta, Sheikh Ul Alam, Somen Chowdhury, Razaul Karim et al.
Bangladesh Critical Care Journal
Pneumonia and Respiratory Infections
article

Hemorrhagic Transformation in Pneumococcal Meningitis: A Rare but Devastating Complication

Vikas Dutta, Sheikh Ul Alam, Somen Chowdhury, Razaul Karim, Shambaditya Das, Rajesh Barua, Ayesha Uddin, Emran Hossain, J. Hasan, Shantanu Mohajan, Abrar Jahin, Tarek Bin Kashem, Saima Jabin
article en

Abstract

Bacterial meningitis is a neurological emergency with significant morbidity and mortality. Streptococcus pneumoniae is the leading cause in adults, with complications such as cerebral infarction, hydrocephalus, and seizures. Haemorrhagic transformation is extremely rare, reported in 2–9% of cases, but is associated with poor prognosis. We report a case of pneumococcal meningitis complicated by extensive frontal lobe and cerebellar haemorrhages. The patient presented with classic meningitis symptoms and rapidly developed a generalized tonic–clonic seizure. Neuroimaging revealed multiple haemorrhages without vascular malformations, hypertension, anticoagulant exposure, or coagulopathy. Venous sinus thrombosis was excluded. Systemic sepsis and vasculitis were considered the likely contributors to haemorrhagic transformation. Despite the severity, the patient showed significant neurological recovery following targeted antibiotics, intensive care, and multidisciplinary rehabilitation. This case emphasizes the need for early neuroimaging in meningitis patients with neurological decline, even in the absence of vascular risk factors, to enable timely recognition and intervention. Bangladesh Crit Care J September 2025; 13 (2): 120-123

Bangladesh Critical Care JournalVol. 13(2)
Chittagong Medical College (BD), Chattagram Maa-O-Shishu Hospital Medical College (BD)
Openalex Percentile: Top 61%
Pneumonia and Respiratory Infections
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