Integrated network pharmacology and clinical study to reveal the efficacy and tolerability of Huoxue Tongjiang decoction for the treatment of non-erosive reflux disease-related symptoms
HTD significantly alleviates reflux, heartburn, and retrosternal pain in NERD, improves quality of life, reduces recurrence, and demonstrates duration-dependent efficacy. Its anti-inflammatory mechanisms may involve TNF and HIF-1 pathways, with no safety concerns observed.
Authors
- Yanxia Gong
- Peicai Li
- Jiannan Jia
- Lei Yang (ORCID: https://orcid.org/0000-0003-3284-5617)
- Yanping Tang (ORCID: https://orcid.org/0000-0003-1683-9356)
- Lei Liu (ORCID: https://orcid.org/0000-0002-4604-4629)
Institutions
- Tianjin Nankai Hospital (CN)
- Tianjin Hospital (CN)
Publication Details
- Journal
- Journal of Translational Internal Medicine
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1515/jtim-2025-0043
- Citations
- 1
- Primary Topic
- Gastroesophageal reflux and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.81