Arginine-mediated inhibition of macrophage apoptosis by Escherichia coli nissle 1917 in Salmonella typhimurium-induced intestinal inflammation
Mechanistically, arginine suppresses S. Tm-driven B-cell lymphoma-2 (BCL2) downregulation, inhibiting apoptosis. Further analysis revealed that arginine may disrupt the interaction between ribosomal protein S3 (RPS3) and serine/serine and arginine rich splicing factor 3 (SRSF3), thereby further suppressing the expression of apoptosis-related proteins induced by S. Tm. Our research offers new targets and approaches for treating bacterial infection-induced intestinal inflammation.
Authors
- Chen Shang (ORCID: https://orcid.org/0000-0002-2577-9220)
- Changlin Zhou (ORCID: https://orcid.org/0000-0001-5910-4259)
- Lu Zhang (ORCID: https://orcid.org/0000-0002-4626-5990)
- Jiahui Yang (ORCID: https://orcid.org/0000-0003-3777-8222)
- Yanyan Chu
- Lingman Ma (ORCID: https://orcid.org/0000-0002-4114-6079)
- Jiarui Cao (ORCID: https://orcid.org/0009-0005-4073-0344)
- Qixue Shi
Institutions
- China Pharmaceutical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1684234
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00