Efficacy and Safety of Laser Treatment in Vulvar Lichen Sclerosus: A Systematic Review
Laser therapy improves symptoms/signs, QoL, and histological outcomes in VLS, with good safety and tolerability. However, the evidence supporting its use as a monotherapy is limited, and benefits for anti-inflammatory, anti-fibrotic, scar-preventive, or anticarcinogenic effects remain unproven. Large-scale, long-term, and high-quality trials are needed, and future research should establish standardized Core Outcome and Measurement Sets to optimize VLS management.
Authors
- Yajing Wang (ORCID: https://orcid.org/0000-0002-1326-1459)
- Xiaoyu Niu (ORCID: https://orcid.org/0000-0002-8313-2097)
- Qiao Li (ORCID: https://orcid.org/0000-0001-8059-2293)
- Jian Meng (ORCID: https://orcid.org/0000-0002-4161-5680)
- Yueyue Chen (ORCID: https://orcid.org/0000-0002-2568-7772)
- Dongmei Wei
Institutions
- Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
Publication Details
- Journal
- Lasers in Surgery and Medicine
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1002/lsm.70062
- Primary Topic
- Genital Health and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Science and Technology of Sichuan Province
- Sichuan University
- Health Commission of Sichuan Province
- National Key Research and Development Program of China