Evaluating lymphocyte change rate and lactate as predictors of prognosis in critical COVID-19 patients in the intensive care unit
In summary, lymphocyte change rate combined with LAC had the greatest predictive value for COVID-19 ICU patient prognosis, while respiratory-related indicators had no significant relationship with prognosis, so we suggest the increase of LAC in COVID-19 patients may be caused by microcirculatory disturbances.
Authors
- Jin Yang (ORCID: https://orcid.org/0000-0001-6004-955X)
- Jiaxi Lin (ORCID: https://orcid.org/0000-0003-4171-7457)
- Jun Jin (ORCID: https://orcid.org/0000-0002-8778-5247)
- Zhen Chen (ORCID: https://orcid.org/0000-0003-1603-4638)
- Liquan Chen (ORCID: https://orcid.org/0000-0001-5058-9552)
- Yuxiu Tang
- Xueke Liu (ORCID: https://orcid.org/0000-0002-0471-7629)
- Wei Yao (ORCID: https://orcid.org/0009-0000-1964-164X)
Institutions
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fcimb.2025.1532174
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Graduate Research and Innovation Projects of Jiangsu Province