Immune dysregulation and endothelial dysfunction associate with a pro-thrombotic profile in Long COVID
These findings support a multifactorial model of LC involving immune dysregulation and persistent endothelial damage that led to coagulation abnormalities and a pro-thrombotic profile, supporting that LC is more closely related to a sustained, uncontrolled inflammatory response rather than immunodeficiency, and underscoring the value of multidimensional biomarker profiling for guiding clinical management and prevention strategies.
Authors
- Guiomar Casado
- Mayte Coiras (ORCID: https://orcid.org/0000-0001-6464-5770)
- María Aránzazu Murciano-Antón
- Mayte Pérez‐Olmeda (ORCID: https://orcid.org/0000-0003-4553-5423)
- Miguel Cervero (ORCID: https://orcid.org/0000-0001-9387-7917)
- Gemma Moncunill
- Montserrat Torres (ORCID: https://orcid.org/0000-0001-8776-8925)
- Javier García‐Pérez (ORCID: https://orcid.org/0000-0001-7551-7803)
- Francisco Pozo (ORCID: https://orcid.org/0000-0003-1828-733X)
- Susana Domínguez-Mateos
- Clara Sánchez-Menéndez (ORCID: https://orcid.org/0000-0002-9856-6349)
- Elena Mateos (ORCID: https://orcid.org/0000-0002-5449-7337)
- Daniel Fuertes (ORCID: https://orcid.org/0000-0002-5746-2199)
- Alicia Simón-Rueda
- Marta Massanella
Institutions
- Universidad Nacional de Educación a Distancia (ES)
- Instituto de Salud Carlos III (ES)
- Hospital Clínico San Carlos (ES)
- Departament de Salut (ES)
- Spanish Clinical Research Network (ES)
- Madrid Health Service (ES)
- Primary HealthCare (MT)
- Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol (ES)
- Universidad Alfonso X el Sabio (ES)
- Barcelona Institute for Global Health (ES)
- Universitat de Barcelona (ES)
- Universidad Politécnica de Madrid (ES)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1613195
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Comunidad de Madrid
- Instituto de Salud Carlos III