TNF-α-mediated downregulation of CD36 and phagocytic impairment of alveolar macrophages via upregulation of ADAM17 in asthma
AMs from OVA-induced mice displayed significantly impaired phagocytic capacity. Airway TNF-α upregulated ADAM17, which in turn downregulated CD36 expression on AMs, ultimately suppressing their phagocytic function.
Authors
- Minyu Xie (ORCID: https://orcid.org/0000-0003-1146-2297)
- Meng Niu (ORCID: https://orcid.org/0000-0003-1055-3728)
- Jiaqi Yan (ORCID: https://orcid.org/0000-0002-5836-0987)
- Feifei Shang (ORCID: https://orcid.org/0000-0001-7648-9568)
- Mengqing Hua (ORCID: https://orcid.org/0000-0002-5751-3566)
- Fan Wu (ORCID: https://orcid.org/0000-0002-7275-7649)
- Ya Li
- Shujun Guo
- Han Huang (ORCID: https://orcid.org/0000-0003-3353-2970)
- Shu Dong
- Yanni Hao (ORCID: https://orcid.org/0000-0002-2300-9951)
- Chuanwang Song (ORCID: https://orcid.org/0000-0002-7374-0443)
- Wenwen Wu
- Xiangnan Tao
- Yulin Du
- Xingyue Liu
- Yingzi Chen (ORCID: https://orcid.org/0000-0002-6415-0011)
Institutions
- Bengbu Medical College (CN)
- Anhui Medical University (CN)
- The Second Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1663513
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00