Gut microbiome as a potential mediator linking sexual behaviors to immune profiles in HIV-negative men who have sex with men: a multi-omics study
Our study indicates that gut microbiome partially mediates the immunomodulatory effects of sexual behaviors, providing mechanistic insights into HIV susceptibility. These findings underscore the gut-immune axis as a potential target for HIV prevention strategies in high-risk MSM.
Authors
- Kangjie Li (ORCID: https://orcid.org/0000-0001-9287-7392)
- Biao Xie (ORCID: https://orcid.org/0000-0002-7474-4868)
- Xiaoni Zhong (ORCID: https://orcid.org/0000-0002-8035-1841)
- Jiaxiu Liu (ORCID: https://orcid.org/0000-0003-0086-8558)
- Tian Liu (ORCID: https://orcid.org/0000-0002-4932-2727)
- Wenlong Li (ORCID: https://orcid.org/0000-0002-5614-9678)
- Cong Zhang (ORCID: https://orcid.org/0009-0009-7547-5119)
- Yi Tao (ORCID: https://orcid.org/0000-0002-5533-6252)
- Haijiao Zeng
- Bing Lin (ORCID: https://orcid.org/0000-0002-3920-724X)
- Xiaohua Zhong
- S. Huo
- Jielian Deng
Institutions
- Army Medical University (CN)
- Medical College of Wisconsin (US)
- Sichuan International Studies University (CN)
- Daping Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Public Health Medical Center (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1659556
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00