Reducing stress and alcohol-related behaviors by targeting D1-CRHR1 receptor interactions in the amygdala
Our findings suggest D1-CRHR1 interactions within the ITC of the amygdala in response to stress, alcohol behavior, and the development of dependence, thereby providing a novel mechanism that may be targetable by therapeutic polypharmacological interference.
Authors
- Oliver von Bohlen und Halbach (ORCID: https://orcid.org/0000-0002-2613-2517)
- Rainer Spanagel (ORCID: https://orcid.org/0000-0003-2151-4521)
- Wolfgang H. Sommer (ORCID: https://orcid.org/0000-0002-5903-6521)
- Dasiel O. Borroto‐Escuela (ORCID: https://orcid.org/0000-0002-5736-373X)
- Kjell Fuxé (ORCID: https://orcid.org/0000-0001-8491-4288)
- Roberto Rimondini (ORCID: https://orcid.org/0000-0003-4099-513X)
- Francesco Giannone (ORCID: https://orcid.org/0000-0002-0364-7374)
- Kay Jüngling (ORCID: https://orcid.org/0000-0001-9639-8815)
- Jan M. Deussing (ORCID: https://orcid.org/0000-0002-9329-5252)
- Rick E. Bernardi
- Miguel Pérez de la Mora (ORCID: https://orcid.org/0000-0003-1520-4439)
- Laura Broccoli
- Anita C. Hansson (ORCID: https://orcid.org/0000-0003-1821-3920)
- Anika Hoppe
- Hans-Christian Pape
Institutions
- Heidelberg University (DE)
- University of Münster (DE)
- Universitätsmedizin Greifswald (DE)
- University Hospital Heidelberg (DE)
- Karolinska Institutet (SE)
- Central Institute of Mental Health (DE)
- Max Planck Institute of Psychiatry (DE)
- Universidad Nacional Autónoma de México (MX)
- University of Bologna (IT)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fphar.2025.1677510
- Citations
- 1
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 1.11
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung