Characterizing sleep-related phenotypes with patient-reported outcomes in Parkinson’s disease

Poor sleepers showed uniformly higher PRO-PD burden, with a non-motor phenotype consisting of insomnia, fatigue, anxiety, and depression consistent with prior reports. The PRO-PD further identified additional equally-correlated symptoms, such as poor balance, lacking motivation, and social withdrawal providing expanded perspective. These findings highlight the need for routine sleep assessments in PD management and suggest that interventions targeting sleep disturbances may alleviate symptom burden and improve QoL. Future longitudinal studies could help establish causality and explore therapeutic strategies to improve sleep quality in PD.