Sulforaphane alleviates hepatocyte pyroptosis via activating Nrf2-HO-1 signaling during septic acute liver injury
SFN ameliorated liver injury and inflammation during LPS-induced ALI by suppressing hepatocyte pyroptosis via the activation of Nrf2/HO-1 signaling. This study provides new evidence for the potential treatment of ALI with SFN.
Authors
- Yong Qi Xie (ORCID: https://orcid.org/0000-0003-3574-2883)
- Lei Chen (ORCID: https://orcid.org/0000-0001-7146-4636)
- Li Liu
- Weina Chen (ORCID: https://orcid.org/0000-0002-9474-6262)
- Min Liu (ORCID: https://orcid.org/0000-0002-2665-0584)
- Hide S. Huang
- Shiying Xie
Institutions
- Sun Yat-sen University (CN)
- Zunyi Medical University (CN)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
- Fuzhou Second Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fphar.2025.1690067
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00