Lanthanum enhances biomass and bioactive metabolite production in Glycyrrhiza uralensis via coordinated gene regulation
The results demonstrate that La enhances the accumulation of glycyrrhizic acid, liquiritin, and liquiritigenin via a dual mechanism that simultaneously increases biomass (thereby expanding the precursor pool) and upregulates the expression of key rate-limiting enzyme genes in their biosynthetic pathways. This synergistic action ultimately leads to elevated metabolite production. Our study thereby elucidates the mechanism by which La enhances bioactive metabolite yields in <i>Glycyrrhiza uralensis</i>, proposing a novel strategy for applying rare earth elements to improve the production of valuable compounds in medicinal plants.
Authors
- Yuqin Wang (ORCID: https://orcid.org/0000-0002-3063-3066)
- Yuanyang Shao (ORCID: https://orcid.org/0000-0002-0585-4617)
- Huiqin Zou (ORCID: https://orcid.org/0000-0003-3066-6180)
- Yushi Wang (ORCID: https://orcid.org/0000-0003-3443-9786)
- Xingyu Guo (ORCID: https://orcid.org/0000-0002-0069-1732)
- Lei Wang (ORCID: https://orcid.org/0000-0001-5320-1787)
- Yonghong Yan
- Yunhao Zhu
- Enai Zhai
Institutions
- Beijing University of Chinese Medicine (CN)
- First Affiliated Hospital of Henan University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Luoyang Orthopedic-Traumatological Hospital of Henan Province (CN)
Publication Details
- Journal
- Frontiers in Plant Science
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fpls.2025.1696545
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00