Integrating bioinformatics and molecular experiments to reveal the critical role of the cellular energy metabolism-related marker PLA2G1B in COPD epithelial cells
This study identified six CEM-related biomarkers (<i>CYP1B1</i>, <i>CA3</i>, <i>AHRR</i>, <i>MGAM</i>, <i>PNMT</i>, and <i>PLA2G1B</i>) in COPD and established a corresponding prognostic model. Furthermore, <i>in vitro</i> and <i>in vivo</i> experiments validated the regulatory role of PLA2G1B in epithelial cell inflammation, oxidative stress, and apoptosis, thereby elucidating the mechanism underlying CEM in COPD and potentially uncovering novel therapeutic targets for drug development.
Authors
- Jun Shi (ORCID: https://orcid.org/0000-0002-2551-4337)
- Zihan Wang (ORCID: https://orcid.org/0009-0005-3011-2171)
- Xiaoyan Gai (ORCID: https://orcid.org/0000-0002-3784-4317)
- Yafei Rao
- Yue Zhang (ORCID: https://orcid.org/0000-0001-7856-7451)
- Danyang Li (ORCID: https://orcid.org/0009-0007-9722-8798)
- Yigui Luo (ORCID: https://orcid.org/0000-0002-9775-7346)
- Yuqiang Pei
- Yongchang Sun
Institutions
- Peking University (CN)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1666195
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China