CD155-TIGIT/CD96/CD226 immune checkpoint axis interacting with tumor-infiltrating lymphocytes to exhibit diverse prognostic effects on breast cancer: a cohort study
The CD155-CD226/TIGIT/CD96 immune checkpoint complex expressed on both TME TC and TILs, and interacted with TILs to exhibit diverse prognosis effect on BC. The immunotherapy against these checkpoint proteins should check the expression on both TC and TILs and further studies should explore the molecule complex collectively for comprehensive prediction of BC prognosis.
Authors
- Jingjing Yin (ORCID: https://orcid.org/0000-0003-4843-613X)
- Keyu Yuan
- Yanjie Zhao (ORCID: https://orcid.org/0000-0003-0831-6395)
- Qingkun Song (ORCID: https://orcid.org/0000-0002-1159-257X)
- Yanping Li (ORCID: https://orcid.org/0000-0001-8123-6311)
- Xin Ou (ORCID: https://orcid.org/0000-0002-0316-9958)
- Shuzhen Lyu (ORCID: https://orcid.org/0000-0002-2341-966X)
- Feng Shi (ORCID: https://orcid.org/0000-0002-1850-7796)
- Quan Zhou (ORCID: https://orcid.org/0000-0002-8856-5836)
- Jiangping Wu (ORCID: https://orcid.org/0000-0002-6602-6452)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Beijing YouAn Hospital (CN)
- Beijing Shijitan Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1649078
- Citations
- 2
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- Beijing Municipal Health Commission