Pterostilbene inhibits non-small cell lung cancer progression by activating the STING pathway and enhancing antitumor immune response
Our findings elucidate a dual mechanism whereby PTE directly kills NSCLC cells via ROS-mediated apoptosis and simultaneously reinvigorates antitumor immunity through STING pathway activation. This positions PTE as a promising candidate for combination immunotherapy in NSCLC.
Authors
- Pan Xu (ORCID: https://orcid.org/0000-0001-9099-5651)
- Zebo Jiang
- H. Y. Huang (ORCID: https://orcid.org/0000-0002-0843-0000)
- Han Xie
- Cong Xu (ORCID: https://orcid.org/0009-0000-2283-9243)
- Donghui Huang (ORCID: https://orcid.org/0000-0002-2291-2524)
- Liping Kang
Institutions
- Northeastern University (US)
- Sun Yat-sen University (CN)
- Jiangsu Cancer Hospital (CN)
- The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine (CN)
- Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1622284
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province