A Comprehensive Overview of the Clinical, Electrophysiological, and Neuroimaging Features of <scp>BPAN</scp> : Insights From a New Case Series
This study contributes further to our understanding of the heterogeneous clinical spectrum of BPAN. Genotype-phenotype correlation in BPAN remains unclear due to the absence of sufficiently large cohorts in the literature, including the present study. Nevertheless, even within this small sample, the phenotypic heterogeneity observed among individuals harboring the same genotype highlights the biological complexity of the disease. Neuroimaging findings may reflect progressive and widespread neurological involvement in an age-dependent pattern, whereas EEG data suggest that epilepsy severity tends to decrease after adolescence.
Authors
- Zuhal Yapıcı (ORCID: https://orcid.org/0000-0002-9349-565X)
- Seda Süsgün (ORCID: https://orcid.org/0000-0001-9689-3111)
- Murat Emre
- Ayşe Deniz Elmalı (ORCID: https://orcid.org/0000-0001-6380-9550)
- Nerses Bebek (ORCID: https://orcid.org/0000-0002-4749-1471)
- Berril Donmez
- Gül Yalçın Çakmaklı (ORCID: https://orcid.org/0000-0001-8545-7939)
- Raif Çakmur (ORCID: https://orcid.org/0000-0002-0194-7779)
- Sı̇bel Aylı̇n Uğur İşerı̇ (ORCID: https://orcid.org/0000-0002-5790-6853)
- Pınar İşçen (ORCID: https://orcid.org/0000-0002-2874-9473)
- Pınar Topaloğlu
- Bülent Elibol (ORCID: https://orcid.org/0000-0001-5015-0152)
- İbrahim Kamacı
- Özgü Kizek (ORCID: https://orcid.org/0000-0001-6206-1835)
- Berfin Gulkaya Guzel (ORCID: https://orcid.org/0000-0002-8690-4136)
Institutions
- Dokuz Eylül University (TR)
- Bezmiâlem Vakıf Üniversitesi (TR)
- HUN-REN Institute of Experimental Medicine (HU)
- Hacettepe University (TR)
- Istanbul University (TR)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1002/acn3.70220
- Primary Topic
- Neurological diseases and metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ankara Universitesi
- İstanbul Medeniyet Üniversitesi
- İstanbul Medipol Üniversitesi
- Ege Üniversitesi
- Türkiye Bilimler Akademisi
- Atilim Üniversitesi
- Hacettepe Üniversitesi
- Eskişehir Osmangazi Üniversitesi
- Istanbul Teknik Üniversitesi
- Marmara Üniversitesi
- Istanbul Kalkinma Ajansi
- Istanbul Üniversitesi-Cerrahpasa