Aurantii Fructus extract alleviates DSS-induced colitis in mice via regulating NF-κB and Nrf2/HO-1 signaling pathways and modulating intestinal microbiota

The findings demonstrate that AFE confers a protective effect against DSS-induced UC. The underlying mechanism is associated with the inhibition of the NF-κB pathway, activation of the Nrf2/HO-1 antioxidant pathway, enhancement of the intestinal barrier, and restoration of gut microbiota homeostasis.

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Publication Details

Journal
Frontiers in Nutrition
Published
2025-10-16
DOI
https://doi.org/10.3389/fnut.2025.1661040
Citations
1
Primary Topic
Morinda citrifolia extract uses
Type
article
Field-Weighted Citation Impact
2.38
Controls
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article

Aurantii Fructus extract alleviates DSS-induced colitis in mice via regulating NF-κB and Nrf2/HO-1 signaling pathways and modulating intestinal microbiota

XiangDan Liu, Jiayuan Zhu, Junbao Yu, RiBao Zhou et al.
1 citations
Frontiers in Nutrition
Morinda citrifolia extract uses
2.38
article

Aurantii Fructus extract alleviates DSS-induced colitis in mice via regulating NF-κB and Nrf2/HO-1 signaling pathways and modulating intestinal microbiota

XiangDan Liu, Jiayuan Zhu, Junbao Yu, RiBao Zhou, Wen-ya Mei, XiaoRong Liu, ZhiHui Wang
article en
1 citations

Abstract

The findings demonstrate that AFE confers a protective effect against DSS-induced UC. The underlying mechanism is associated with the inhibition of the NF-κB pathway, activation of the Nrf2/HO-1 antioxidant pathway, enhancement of the intestinal barrier, and restoration of gut microbiota homeostasis.

Frontiers in NutritionVol. 12
Hunan University of Traditional Chinese Medicine (CN), Soil and Fertilizer Institute of Hunan Province (CN), Hunan Academy of Traditional Chinese Medicine (CN), Education Department of Hunan Province (CN)
Openalex Percentile: Top 9%
Morinda citrifolia extract uses
2.38
DOIOpen Access PDFOpenAlex
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