Correlation between cortical morphology and synaptic-associated proteins levels in poststroke aphasia: a pilot study
In summary, patients with PSA exhibit distinct alterations in synaptic protein expression accompanied by widespread gray matter atrophy, marked by reduced GMV, CT, and SULC, particularly in language-related regions. These structural and molecular interrelationships suggest that early recovery involves neuroplastic mechanisms, potentially mediated via synaptic plasticity as well as structural adaptation. Our findings provide novel multidimensional insights into the neurobiological substrate of PSA and highlight promising pathways for future mechanistic and therapeutic research.
Authors
- Jiaqin Huang (ORCID: https://orcid.org/0000-0001-7350-1146)
- Danli Zhang (ORCID: https://orcid.org/0000-0002-6579-4724)
- Yun Cao (ORCID: https://orcid.org/0000-0001-7716-2997)
- Xiaojing Lei
- Jingling Chang (ORCID: https://orcid.org/0000-0002-7881-8174)
- Zhongjian Tan
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- Beijing Jishuitan Hospital (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
- Beijing Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Psychology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fpsyg.2025.1636531
- Primary Topic
- Stroke Rehabilitation and Recovery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China