A proteome-wide association study reveals novel plasma proteins as potential therapeutic targets for metabolic dysfunction-associated steatotic liver disease
This integrative proteomic and genetic study identified NCAN as a key contributor to MASLD pathogenesis. Its consistent association and genetic evidence across two independent cohorts highlight NCAN as a promising therapeutic target that merits further functional investigation.
Authors
- Nanwei Tong (ORCID: https://orcid.org/0000-0002-5395-3660)
- Yiwen Tan
- Wenzeng Deng
- Zhu Feng Yue (ORCID: https://orcid.org/0000-0001-9049-9076)
- Qian Zhong (ORCID: https://orcid.org/0000-0001-8354-5839)
- Chunxia Wang (ORCID: https://orcid.org/0000-0002-8214-6905)
- Shan Yang (ORCID: https://orcid.org/0000-0003-0583-3637)
Institutions
- Dalian Medical University (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- Qianjiang Central Hospital (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fendo.2025.1664691
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00