Single-cell RNA sequencing analysis reveals cell landscape and gene signatures associated with granulomatous lobular mastitis
To our knowledge, this is the first scRNA-seq study of GLM, identifying 11 major cellular populations and implicating macrophages-especially M1 subtype-as central to disease immunopathology. We report dysregulated expression of CD64, NADPH oxidase components, and TRAIL, prompting the hypothesis that phagocytic function may be impaired and nominating this axis as a potential therapeutic target.
Authors
- Dongxiao Zhang (ORCID: https://orcid.org/0000-0003-3893-4864)
- Xulong Zhang (ORCID: https://orcid.org/0000-0001-7005-992X)
- Junyue Wang (ORCID: https://orcid.org/0000-0001-5211-151X)
- Yifei Zeng (ORCID: https://orcid.org/0000-0002-5488-0483)
- Yudong Li (ORCID: https://orcid.org/0000-0002-4770-6380)
- Mengjie Wang (ORCID: https://orcid.org/0000-0003-3637-4787)
- Min Liu (ORCID: https://orcid.org/0000-0002-6385-8077)
- Xiaolong Xu (ORCID: https://orcid.org/0000-0001-6254-5864)
Institutions
- Beijing University of Chinese Medicine (CN)
- Capital Medical University (CN)
- Beijing Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1624640
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Capital Medical University
- Beijing University of Chinese Medicine