Palladium‐Catalyzed Stereoselective Difunctionalization of Skipped 1,4‐Enynes With Imines and Organoboronic Acids
Presented herein is a palladium-catalyzed three-component reaction involving skipped 1,4-enynes, imines and organoboronic acids, proceeding in a cascade isomerization, vinylogous addition and Suzuki coupling process. A range of chiral homoallylic amines are constructed in moderate to good yields with excellent regio- and (E,E)-selectivity and fair to high enantioselectivity.
Authors
- Qiu Liu (ORCID: https://orcid.org/0009-0002-7977-9338)
- Wei Du (ORCID: https://orcid.org/0000-0003-4162-1471)
- Bo Zhu (ORCID: https://orcid.org/0000-0001-8231-5169)
- Zhi‐Chao Chen
- Xiang Qin (ORCID: https://orcid.org/0000-0002-1998-595X)
- Xiaojun Wang (ORCID: https://orcid.org/0000-0001-8049-5020)
- Ying‐Chun Chen (ORCID: https://orcid.org/0000-0003-1902-0979)
Institutions
- Chengdu Medical College (CN)
- Sichuan University (CN)
Publication Details
- Journal
- Chemistry - An Asian Journal
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1002/asia.202500873
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00