Vitamin B6 (Pyridoxal 5′ Phosphate) antagonises carotid body P2X3 receptors in hypertension
Our findings suggest that PLP binds to and antagonises P2X3R and is a viable candidate for larger clinical trials to treat CB dysregulation in cardiovascular diseases.
Authors
- Melissa L. Bates (ORCID: https://orcid.org/0000-0002-2605-0984)
- Olivia M. S. Gold
- Marcella Bassetto (ORCID: https://orcid.org/0000-0002-2491-5868)
- Samuel J. Fountain (ORCID: https://orcid.org/0000-0002-6028-0548)
- Pratik Thakkar (ORCID: https://orcid.org/0000-0003-2366-3862)
- Jui‐Lin Fan (ORCID: https://orcid.org/0000-0002-4413-5615)
- James P. Fisher (ORCID: https://orcid.org/0000-0001-7851-9222)
- Thalia Babbage
- Fiona D. McBryde (ORCID: https://orcid.org/0000-0002-5687-9101)
- Audrys G. Pauža (ORCID: https://orcid.org/0000-0001-9635-8872)
- Igor Felippe (ORCID: https://orcid.org/0000-0002-8582-2104)
- Julian F.R. Paton (ORCID: https://orcid.org/0000-0002-7527-5493)
- Riyadh Shaheen
- Matthew Dawes
Institutions
- University of East Anglia (GB)
- University of Iowa (US)
- University of Auckland (NZ)
- An-Najah National University (PS)
- The Centre for Health (New Zealand) (NZ)
- European Society for Blood and Marrow Transplantation (NL)
- Cardiff University (GB)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1093/cvr/cvaf195
- Citations
- 2
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 2.22
Funders
- British Heart Foundation
- National Heart Foundation of New Zealand