Trace element-linked DNA methylation sites and their association with type 2 diabetes and cardiovascular diseases: EPIC-Potsdam cohort study
Serum copper levels are inversely associated with a number of CpG sites. Methylation levels at these CpG sites were inversely associated with developing T2D and CVD. These findings may provide new insights on understanding the increased risk of T2D and CVD with elevated blood copper levels.
Authors
- Olga Kuxhaus
- Tanja Schwerdtle (ORCID: https://orcid.org/0000-0002-4873-7488)
- Hajo Haase (ORCID: https://orcid.org/0000-0002-1622-8718)
- Lutz Schomburg (ORCID: https://orcid.org/0000-0001-9445-1555)
- Matthias Bernd Schulze (ORCID: https://orcid.org/0000-0002-0830-5277)
- Anna P. Kipp (ORCID: https://orcid.org/0000-0002-3307-1038)
- Fabian Eichelmann (ORCID: https://orcid.org/0000-0002-3975-5596)
- Barbaros Eroglu
Institutions
- University of Potsdam (DE)
- Aptiv (Germany) (DE)
- Max Rubner Institut (DE)
- Deutsches Diabetes-Zentrum e.V. (DE)
- German Center for Diabetes Research (DE)
- German Institute of Human Nutrition (DE)
- Heinrich Heine University Düsseldorf (DE)
- Technische Universität Berlin (DE)
- Friedrich Schiller University Jena (DE)
- Charité - Universitätsmedizin Berlin (DE)
- Robert Bosch (Germany) (DE)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1186/s13148-025-01991-0
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81