Angiotensin II type 1 receptor antibodies as a contributor to microvascular inflammation in kidney transplant recipients: insights from statistical and artificial intelligence based approaches
The presence of AT1R antibodies may be associated with the development of microvascular inflammation, potentially contributing to allograft injury in a subset of cases of kidney transplant recipients. High AT1R abs titers (>12 U/ml) were particularly important, while lower levels did not show the meaningful association. These findings underscore the importance of broadening immunologic surveillance beyond conventional anti-HLA antibody screening.
Authors
- Marta Kepinská (ORCID: https://orcid.org/0000-0002-0935-5663)
- Mirosław Banasik (ORCID: https://orcid.org/0000-0002-0588-1551)
- Dariusz Janczak (ORCID: https://orcid.org/0000-0003-4671-9128)
- Agnieszka Hałoń (ORCID: https://orcid.org/0000-0003-4240-7899)
- Jakub Mizera (ORCID: https://orcid.org/0000-0002-8112-9257)
- Piotr Donizy (ORCID: https://orcid.org/0000-0002-8729-6216)
- Maciej Pondel (ORCID: https://orcid.org/0000-0002-1978-6571)
Institutions
- University of Wrocław (PL)
- Wroclaw University of Economics and Business (PL)
- Wroclaw Medical University (PL)
- University of Business in Wrocław (PL)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1659939
- Citations
- 1
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.99
Funders
- Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu
- Agencja Badań Medycznych