MUC1 alleviates PM2.5-induced airway inflammation by inhibiting the IRAK4/NF-κB/NLRP3 mediated pyroptosis in airway epithelial cells
MUC1 is upregulated in airway epithelial cells upon PM2.5 exposure and serves as a key endogenous inhibitor of airway inflammation. It exerts its anti-inflammatory and anti-pyroptotic effects by suppressing IRAK4 phosphorylation, thereby modulating downstream NF-κB/NLRP3/GSDMD signaling. These findings highlight MUC1 as a potential therapeutic target for PM2.5-induced airway inflammatory diseases.
Authors
- Wenju Lu (ORCID: https://orcid.org/0000-0002-5035-9287)
- Yuanyuan Li
- Chaowei Wen (ORCID: https://orcid.org/0000-0003-2877-8810)
- Wei Liu (ORCID: https://orcid.org/0000-0003-1792-2151)
- Ruijuan Guan (ORCID: https://orcid.org/0000-0002-0523-7459)
- Tao Zhang (ORCID: https://orcid.org/0000-0002-2980-6281)
- Yuan Liang (ORCID: https://orcid.org/0000-0002-1861-4479)
- Jingyi Xu (ORCID: https://orcid.org/0000-0002-4742-640X)
- Kai Yang (ORCID: https://orcid.org/0000-0002-5924-6844)
- Jian Wang (ORCID: https://orcid.org/0000-0003-0357-0263)
- You Zhou (ORCID: https://orcid.org/0009-0008-8780-412X)
- Feng Wei (ORCID: https://orcid.org/0000-0002-8241-8456)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fimmu.2025.1653184
- Citations
- 2
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61