SynthSR-generated 3D T1-weighted MRI from routine 2D clinical images: Validation for VSRAD analysis
Although SynthSR-based images produced systematically different absolute values, they preserved rank-order correlations and maintained diagnostic performance comparable to that of standard 3D volumes in VSRAD analysis. Considering that conventional 3D acquisitions are often difficult to obtain in elderly patients undergoing dementia screening, SynthSR-based reconstruction may represent a practical alternative in routine clinical practice, particularly for Score 1 "Severity," the most clinically relevant marker of hippocampal atrophy.
Authors
- Tetsuya Sakai (ORCID: https://orcid.org/0000-0002-6720-963X)
- Tetsuro Sekine (ORCID: https://orcid.org/0000-0003-1547-6696)
- Atsumi Takenobu
- A. Morita (ORCID: https://orcid.org/0000-0003-0494-1206)
- Tsukasa Koike (ORCID: https://orcid.org/0000-0002-9931-0716)
- Takahiro Tsuchiya
- Akira Teraoka
Institutions
- Waseda University (JP)
- Taoka Hospital (JP)
- Japan Organization of Occupational Health and Safety (JP)
- Nippon Medical School Hospital (JP)
- Tokyo Rosai Hospital (JP)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fneur.2025.1645891
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science