Real-world brain volumetry in multiple sclerosis: importance of methodological consistency and clinical relevance of gray matter atrophy
Using automated brain volumetry with post-acquisition harmonization to address scanner variability, we did not detect accelerated BVL in this real-world MS cohort compared to healthy individuals. Nonetheless, GM volume loss was found to be clinically relevant in MS.
Authors
- Joke Temmerman (ORCID: https://orcid.org/0000-0001-8102-6760)
- Jeroen Van Schependom (ORCID: https://orcid.org/0000-0003-1200-5872)
- Guy Nagels (ORCID: https://orcid.org/0000-0002-2597-0383)
- Mandy Melissa Jane Wittens (ORCID: https://orcid.org/0000-0001-5253-3106)
- Sebastiaan Engelborghs (ORCID: https://orcid.org/0000-0003-0304-9785)
- Ayla Pauwels (ORCID: https://orcid.org/0000-0002-7874-3168)
- Maria Bjerke (ORCID: https://orcid.org/0000-0002-9575-6462)
- Marie D’hooghe (ORCID: https://orcid.org/0000-0002-0917-4176)
- Miguel D’haeseleer (ORCID: https://orcid.org/0000-0003-4378-0089)
- Diana M. Sima (ORCID: https://orcid.org/0000-0002-0118-2905)
- Dirk Smeets (ORCID: https://orcid.org/0000-0003-1153-094X)
- Ann Vanremoortel
Institutions
- Vrije Universiteit Brussel (BE)
- University of Antwerp (BE)
- Karolinska Institutet (SE)
- Universitair Ziekenhuis Brussel (BE)
- Icometrix (Belgium) (BE)
- National MS Center Melsbroek
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-10-16
- DOI
- https://doi.org/10.3389/fneur.2025.1637835
- Citations
- 1
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47