Tartaric acid pellets as a core for extended release of sildenafil citrate: development via solid dispersion and factorial design
This novel extended-release system significantly improves SC solubility and enables prolonged release, which may reduce dosing frequency and adverse effects, enhancing patient adherence. Further studies on stability and pharmacokinetics are warranted to support clinical application.
Authors
- Élcio José Bunhak (ORCID: https://orcid.org/0000-0002-7363-558X)
- Fábio Pinheiro de Souza
- Márcia Nunes da Silva (ORCID: https://orcid.org/0009-0004-5987-5095)
- Isabela Angeli de Lima (ORCID: https://orcid.org/0000-0002-0445-4523)
- Vanderson Galan (ORCID: https://orcid.org/0000-0002-8397-8850)
- Amanda Moscibroski da Silva Bedin
- Jéssika Adriane Janning
- Volnei José Tondo
- Amabili Leal Pieracio
Institutions
- Universidade Estadual do Paraná (BR)
- Propagation Research Associates (United States) (US)
Publication Details
- Journal
- Drug Development and Industrial Pharmacy
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1080/03639045.2025.2571718
- Citations
- 1
- Primary Topic
- Drug Solubulity and Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.79