The 2025 Centers for Disease Control and Prevention Nonoccupational HIV Postexposure Prophylaxis Guidelines: Updated Regimens and Remaining Questions

The United States Centers for Disease Control and Prevention recently released updated guidance on nonoccupational human immunodeficiency virus postexposure prophylaxis. The guidelines introduce coformulated antiretrovirals as a preferred regimen, which will likely positively impact prescribing practices and adherence. However, other barriers to access and uptake remain a challenge.