Marine nutraceuticals as a source of SIRT1 and NRF2 activators for diabetes and aging-related metabolic disorders
Marine ecosystems harbor a remarkable diversity of bioactive compounds with unique chemical structures and potent pharmacological activities. These marine-derived metabolites have gained increasing attention as promising therapeutic agents for metabolic disorders, particularly diabetes and aging-related diseases. This review highlights the emerging roles of marine-sourced Sirtuin 1 (SIRT1) and Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) activators in modulating glucose and lipid metabolism, enhancing antioxidant defense mechanisms, and ameliorating cellular senescence. We summarize the mechanistic pathways by which key marine compounds-such as fucoxanthin, bromophenols, and coral-derived steroids-modulate SIRT1 and NRF2 signaling, potentially providing synergistic effects superior to those of terrestrial or synthetic analogues. The review also addresses the challenges in pharmaceutical formulation and sustainable production, emphasizing the need for advanced biotechnological strategies and innovative delivery systems. While preclinical evidence is compelling, clinical translation remains limited by issues related to bioavailability, safety, and sustainable production. Future research should focus on clinical trials, improved formulations, and sustainable production platforms to unlock the therapeutic potential of marine natural products for diabetes and aging-related metabolic disorders.
Authors
- Dante Saksono Harbuwono (ORCID: https://orcid.org/0000-0002-6006-2719)
- Sidartawan Soegondo (ORCID: https://orcid.org/0000-0001-5914-5042)
- Nurpudji Astuti Taslim (ORCID: https://orcid.org/0000-0003-1349-5367)
- Maulana Bagus Adi Cahyono
- Lucia De Luca (ORCID: https://orcid.org/0000-0002-2287-3633)
- Fahrul Nurkolis (ORCID: https://orcid.org/0000-0003-2151-0854)
- Raymond R. Tjandrawinata (ORCID: https://orcid.org/0000-0003-0461-9874)
- Antonello Santini (ORCID: https://orcid.org/0000-0001-5505-3327)
- Sony Wibisono Mudjanarko (ORCID: https://orcid.org/0000-0001-5941-904X)
- Reggie Surya (ORCID: https://orcid.org/0000-0002-8165-2072)
- Raffaele Romano (ORCID: https://orcid.org/0000-0001-7555-0486)
- Jongky Hendro Prajitno (ORCID: https://orcid.org/0000-0002-1650-2000)
- Edwin Hadinata
- Andri Frediansyah
- Enggar Yusrina Hasyyati
Institutions
- Swiss German University (ID)
- Atma Jaya Catholic University of Indonesia (ID)
- University of Surabaya (ID)
- Binus University (ID)
- Sunan Kalijaga State Islamic University Yogyakarta (ID)
- Universitas Airlangga (ID)
- University of Indonesia (ID)
- Universitas 17 Agustus 1945 Jakarta (ID)
- Universitas Ciputra (ID)
- Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo (ID)
- Department of Agricultural Sciences (RU)
- National Research and Innovation Agency (ID)
- University of Naples Federico II (IT)
- Hasanuddin University (ID)
Publication Details
- Journal
- Diabetology & Metabolic Syndrome
- Published
- 2025-10-16
- DOI
- https://doi.org/10.1186/s13098-025-01981-5
- Citations
- 2
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 1.61