Gout flares following acute stroke: a single-center cohort and a systematic review/meta-analysis
Gout flares occur in one out of every 25 acute stroke patients, particularly in men presenting with acute ischemic stroke within the first week after symptom onset, and frequently involve the paretic limb. In over half of cases, the flare uncovers previously undiagnosed gout or hyperuricemia, emphasizing the need for systematic evaluation, particularly in patients with delirium or impaired communication, where diagnosis may be delayed. Early colchicine initiation warrants consideration given its anti-inflammatory effects and potential to reduce stroke recurrence.
Authors
- Maria Chondrogianni (ORCID: https://orcid.org/0000-0002-8315-5846)
- Maria‐Ioanna Stefanou (ORCID: https://orcid.org/0000-0002-2305-6627)
- Panagiota‐Eleni Tsalouchidou (ORCID: https://orcid.org/0000-0003-2344-6323)
- Aikaterini Theodorou (ORCID: https://orcid.org/0000-0001-7229-2610)
- Georgia Papagiannopoulou (ORCID: https://orcid.org/0000-0003-0052-5678)
- Klearchos Psychogios (ORCID: https://orcid.org/0000-0003-3993-2545)
- Odysseas Kargiotis (ORCID: https://orcid.org/0000-0002-8317-6428)
- Vasiliki Kotsali-Peteinelli
- Lina Palaiodimou (ORCID: https://orcid.org/0000-0001-7757-609X)
- Christos Krogias (ORCID: https://orcid.org/0000-0003-2965-4051)
- Apostolοs Safouris (ORCID: https://orcid.org/0000-0002-9630-6949)
- Elias Panagiotopoulos (ORCID: https://orcid.org/0000-0002-1992-564X)
- Annerose Mengel (ORCID: https://orcid.org/0000-0002-2399-3020)
- Ulf Ziemann (ORCID: https://orcid.org/0000-0001-8372-3615)
- Eleni Bakola (ORCID: https://orcid.org/0000-0002-1691-6609)
- Georgios Tsivgoulis
Institutions
- National and Kapodistrian University of Athens (GR)
- General University Hospital of Patras (GR)
- St. Josef-Hospital (DE)
- Hertie Institute for Clinical Brain Research (DE)
- Metropolitan Hospital (GR)
- University of Tübingen (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Neurological Research and Practice
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1186/s42466-025-00424-w
- Citations
- 1
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 1.43