Chiral Lithium Amides as Key Reagents in Enantioselective Synthesis of 2-Alkylpyridines with Multiple Stereocenters
A direct enantioselective conjugate addition of 2-alkylpyridines enables efficient construction of complex functionalized pyridinyl scaffolds with contiguous stereocenters. This method leverages chiral lithium amides as traceless stereodirecting auxiliaries, operating through defined aggregation of organolithium intermediates to achieve excellent enantio- and diastereocontrol.
Authors
- Leroy Lu
- Armen Zakarian (ORCID: https://orcid.org/0000-0002-9120-1232)
- Priya Kandiyal
- Dyllan P. Ly
Institutions
- University of California, Santa Barbara (US)
- University of California System (US)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1021/jacs.5c13977
- Primary Topic
- Advanced Synthetic Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00