Yeast genomes show how large genomic variations affect trait diversity

Almost-complete genomes of more than 1,000 strains of the single-celled yeast species Saccharomyces cerevisiae have been assembled and integrated with phenotypic (trait) measures of growth and of RNA and protein expression. The analysis shows how large genomic variations called structural variants disproportionately shape traits. Structural variants have a disproportionately large effect on traits such as growth and gene expression.