ADAM8 in macrophages exacerbates sepsis-induced cardiomyopathy by impeding efferocytosis
Our findings identify ADAM8 as a critical regulator of macrophage-mediated inflammation and impaired macrophage efferocytosis in SICM. Targeting ADAM8 or its downstream effectors may represent a novel therapeutic strategy for sepsis-induced cardiac complications.
Authors
- Rong Dong (ORCID: https://orcid.org/0000-0002-2835-0032)
- Zhenjun Ji (ORCID: https://orcid.org/0000-0002-0299-8527)
- Yongjun Li (ORCID: https://orcid.org/0000-0002-0936-2644)
- Zulong Sheng (ORCID: https://orcid.org/0000-0003-4292-2428)
- Jiaqi Guo (ORCID: https://orcid.org/0000-0002-0254-0401)
- Yuyu Yao (ORCID: https://orcid.org/0000-0001-7841-288X)
- Pengfei Zuo (ORCID: https://orcid.org/0000-0002-7780-0845)
- Kongbo Zhu (ORCID: https://orcid.org/0000-0002-0550-0077)
- Hongliang He (ORCID: https://orcid.org/0000-0002-6099-4356)
- Wang Mi (ORCID: https://orcid.org/0009-0008-8005-6472)
- Genshan Ma (ORCID: https://orcid.org/0000-0003-2566-9416)
- Rui Zhang (ORCID: https://orcid.org/0000-0002-1360-2452)
Institutions
- Zhongda Hospital Southeast University (CN)
- Southeast University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1654688
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00