Impact of <i>APOE</i> ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease
APOE ε4 gene dosage is an independent risk factor for cognitive decline and WMH in CSVD patients, independent of traditional vascular risk factors. APOE ε4 may indirectly impair cognitive function by elevating LDL-C levels to exacerbate atherosclerosis and cerebrovascular injury.
Authors
- Sihao Lin (ORCID: https://orcid.org/0000-0001-9561-0941)
- Tingru Jin
- Hang Yang (ORCID: https://orcid.org/0000-0002-7235-8162)
- Jian Wang (ORCID: https://orcid.org/0000-0002-5335-8845)
- Feng Liu (ORCID: https://orcid.org/0000-0002-4442-7028)
- Junru Hu (ORCID: https://orcid.org/0000-0002-4335-1746)
- Yulan Gou
Institutions
- Wuhan No.1 Hospital (CN)
- Wuhan No. 7 Hospital (CN)
- Wuhan No.9 Hospital (CN)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1002/acn3.70224
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00