A predictive nomogram for treatment response in osteonecrosis patients receiving denosumab with UKA: integrating bone turnover markers and functional parameters

Clinically, the 7-point improvement in HSS scores observed in Group B corresponds to a transition from 'poor' to 'good' knee function, while the 0.8-unit increase in femoral neck T-score translates into a 30% reduction in major-fracture risk over 10 years (FRAX-adjusted), indicating meaningful gains in patient mobility, pain relief, and long-term skeletal protection.

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Publication Details

Journal
Endocrine Connections
Published
2025-10-15
DOI
https://doi.org/10.1530/ec-25-0428
Primary Topic
Bone and Joint Diseases
Type
article
Field-Weighted Citation Impact
0.00
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article

A predictive nomogram for treatment response in osteonecrosis patients receiving denosumab with UKA: integrating bone turnover markers and functional parameters

Ling Liu, Guoping Zou, Ke Pu, Yuanyuan Zeng et al.
Endocrine Connections
Bone and Joint Diseases
article

A predictive nomogram for treatment response in osteonecrosis patients receiving denosumab with UKA: integrating bone turnover markers and functional parameters

Ling Liu, Guoping Zou, Ke Pu, Yuanyuan Zeng, RijiangChen
article en

Abstract

Clinically, the 7-point improvement in HSS scores observed in Group B corresponds to a transition from 'poor' to 'good' knee function, while the 0.8-unit increase in femoral neck T-score translates into a 30% reduction in major-fracture risk over 10 years (FRAX-adjusted), indicating meaningful gains in patient mobility, pain relief, and long-term skeletal protection.

Endocrine ConnectionsVol. 14(11)
Fujian Medical University (CN), First Affiliated Hospital of Fujian Medical University (CN)
Openalex Percentile: Top 62%
Bone and Joint Diseases
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