The Role of ARL13B in Mitochondrial Homeostasis in Cultured Human Corneal Endothelial Cells
The findings in this study highlight the importance of ARL13B in cultured HCECs and its impact on mitochondrial function and AQP1 localization. Although ARL13B knockdown did not affect the frequency of primary cilia, it significantly enhanced mitochondrial OXPHOS and led to a shift in AQP1 localization, thus suggesting a functional modulation of metabolism in cultured HCECs.
Authors
- Noriko Horiuchi
- Hideto Deguchi (ORCID: https://orcid.org/0000-0002-9014-8046)
- Hidetoshi Tanioka
- Yusuke Koga (ORCID: https://orcid.org/0000-0003-4875-6598)
- Nobuhiro Hiramoto (ORCID: https://orcid.org/0000-0002-0472-6680)
- Tomoko Yamashita (ORCID: https://orcid.org/0000-0001-5167-1128)
- Chie Sotozono
- Munetoyo Toda (ORCID: https://orcid.org/0000-0002-3988-2536)
Institutions
- Buck Institute for Research on Aging (US)
- Kyoto Prefectural University of Medicine (JP)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1167/iovs.66.13.25
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00