Glucose-Lowering Medication Classes and Cardiovascular Outcomes in Patients With Type 2 Diabetes
In this study, MACE risk varied significantly by medication class, with most protection achieved with sustained treatment with GLP-1RAs followed by SGLT2is, sulfonylureas, and DPP4is. The magnitude of benefit of GLP-1RAs over SGLT2is depended on baseline age, ASCVD, HF, and kidney impairment. These results, along with consideration of cost, availability, and collateral clinical benefits, may inform treatment decisions for adults with T2D.
Authors
- Luis A. Rodríguez (ORCID: https://orcid.org/0000-0001-9694-6842)
- Andrea E. Cassidy‐Bushrow (ORCID: https://orcid.org/0000-0001-8272-4448)
- Holly Finertie (ORCID: https://orcid.org/0000-0003-2732-2694)
- Noel Pimentel
- Alyce S. Adams (ORCID: https://orcid.org/0000-0002-0146-4996)
- Gregg D. Simonson (ORCID: https://orcid.org/0000-0001-5561-2547)
- Lindsey Aurora (ORCID: https://orcid.org/0000-0002-7522-3386)
- Tainayah Thomas (ORCID: https://orcid.org/0000-0001-9094-8556)
- Stephanie Ann Hooker (ORCID: https://orcid.org/0000-0003-4222-7046)
- Lisa K. Gilliam (ORCID: https://orcid.org/0000-0001-7054-1409)
- Caryn Etsuko Shima Oshiro (ORCID: https://orcid.org/0000-0002-0802-9794)
- Andrew John Karter (ORCID: https://orcid.org/0000-0001-5527-316X)
- Sarah Krahe Dombrowski (ORCID: https://orcid.org/0009-0003-7020-3794)
- Patrick J. O’Connor (ORCID: https://orcid.org/0000-0002-2324-6228)
- Romain S. Neugebauer (ORCID: https://orcid.org/0000-0002-6085-4564)
- Eric R. Wright (ORCID: https://orcid.org/0000-0001-5972-3498)
- Wendy Dyer (ORCID: https://orcid.org/0000-0002-8861-5549)
- Margaret B Nolan (ORCID: https://orcid.org/0000-0001-5214-3992)
- Maher Yassin
- Julie A. Schmittdiel (ORCID: https://orcid.org/0000-0001-8995-5345)
- Jasleen Kaur (ORCID: https://orcid.org/0000-0003-0231-7303)
- Sharon Lin (ORCID: https://orcid.org/0000-0002-7923-3979)
- Mark J. van der Laan (ORCID: https://orcid.org/0000-0003-1432-5511)
- G. C. Knowlton
- Jaejin An
- Richard M. Bergenstal
- Keanu Izadian
Institutions
- Regions Hospital (US)
- Kaiser Permanente (US)
- Henry Ford Health System (US)
- Wayne State University (US)
- Henry Ford Hospital (US)
- Kaiser Permanente Center for Health Research (US)
- Kaiser Permanente South San Francisco Medical Center (US)
- HealthPartners (US)
- Michigan State University (US)
- University of California, Berkeley (US)
- Stanford University (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.36100
- Citations
- 4
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 5.18